Vaccinations against infections predisposed by complement deficiencies
Complement deficiencies predispose to an increased susceptibility to infection, in particular caused by Neisseria meningitidis, and to a minor extent by Streptococcus pneumonia and Haemophilus influenza (Table 1, ref 1). While Haemophilus influenzae is only a problem in early childhood and in immunocompromised subjects, the former two are important causes of life-threatening disease in youth and early adolescence or childhood and old age, respectively (refs WA, WB). All three are vaccine-preventable and multivalent and conjugated vaccines should be used (Table WA) - instead of monovalent or polysaccharide vaccines, according to the Advisory Committee on Immunization Practices (ACIP) (ref WA). Guidelines for antimicrobial chemoprophylaxis and for evaluation and management of suspected outbreaks of meningococcal disease are detailed elsewhere (ref WA).